Dianne Medina was born, Maria Patricia Dianne Perez Medina, on November 5, 1986. She is a graduate of AB Communication Arts from Miriam College.
Medina was one of the 12 finalist of Wazzup Wazzup's 2006 Tadjock Search. After winning the search, she became a regular segment host of the satirical comedy news program and appeared as a guest host of Studio 23's morning news and talk show, Breakfast.
In 2007, she was cast as Dianne in the ABS-CBN sitcom, Let's Go, directed by Bobot Mortiz. She was personally offered by Johnny Manahan to join Star Magic after her guest performance in, the now defunct noontime variety show, Wowowee--another show directed by Mortiz. Medina was included in the 15 celebrity contestants of the second season of U Can Dance Version 2. She was also cast as Joy in the second season of Star Magic Presents: Abt Ur Luv--renamed Abt Ur Luv Ur Lyf 2. She made her film debut in the Star Cinema film A Love Story.
She was cast as Teena in the 2008 teen drama, Star Magic Presents: Astigs in Luvin' Lyf. She also made a special appearance in Komiks Presents: Tiny Tony. October of the same year, she was cast as a series regular in the sexy sketch comedy, Banana Split--a spin off of the '90s show Goin' Bananas. Earlier, she played Agatha in the fantasy drama Dyosa, her character was killed off the show due to her commitments to Banana Split. Her stint in Banana Split ended abruptly in 2008 when the management decided to reformat the program.
In 2009, Medina started appearing in TV5 shows, aside from her appearances in ABS-CBN. She was cast as one of the hosts of Flo, a teenage lifestyle program which aired for one season in TV5. She played Kat in Kambal sa Uma and had guest appearances in Your Song Presents: Boystown, Your Song Presents: Feb-ibig and Precious Hearts Romances Presents: Ang Lalaking Nagmahal Sa Akin. She joined the cast of TV5's gag show Lokomoko High in the middle of 2009. She also had a special participation in May Bukas Pa.
Medina started dating fellow Star Magic talent Rodjun Cruz, when both of them were cast in the second season of U Can Dance Version 2.