Bell was raised in Las Vegas, Nevada. She began studying improv at the age of eight. She became a member of the Groundlings. She auditioned for Saturday Night Live, and though she did not join the cast, she became a writer for the show.
Bell appeared in an episode of Curb Your Enthusiasm as an assistant who wears revealing clothing at work. She plays "Jillian Belk" in Workaholics and has a recurring role as Dixie in the fourth and final season of Eastbound and Down. She will appear in the upcoming comedy film 22 Jump Street alongside Jonah Hill" and Channing Tatum.